PROTAC Research

PROTACs (PROteolysis TArgeting Chimeras) are heterobifunctional small molecules containing binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. PROTACs induce targeted protein degradation via the ubiquitin proteasome system. The binding of both moieties results in the formation of a ternary complex between target protein and E3 ligase, leading to polyubiquitination of the target protein, its recognition by the proteasome and subsequent degradation. A key feature of PROTACs is their catalytic mode of action. They dissociate following ubiquitination and rebind to new target proteins, which allows their use at sub-stoichiometric concentrations.

Catalog No.	Name
6P13119	dBET1
6P15119	MS4077
6P15219	MS4078
6P13170	(+)-JQ1
6P15170	Ceritinib