6P13170
(+)-JQ1
Order Information
| Size | Catalog Price |
| 10 mM* 1 mL in DMSO | ￥ 855.00 |
| 1 mg | ￥ 380.00 |
| 5 mg | ￥ 850.00 |
| 10 mg | ￥ 1500.00 |
| 50 mg | ￥ 4950.00 |
| 100 mg | ￥ 7900.00 |
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| Product Name | (+)-JQ1 |
| Alternative Names | JQ-1; JQ1; JQ 1 |
| Formula | C23H25ClN4O2S |
| Molecular Weight | 456.99 |
| IUPAC | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
| CAS No. | 1268524-70-4 |
| Working Concentration | 10 - 15000 nM |
| Bioactivity[2] |
Kd = 49 nM, IC50 = 76.9 nM of BRD4(N) Kd = 59.5 nM of BRD3(N) Kd = 82 nM, IC50 = 32.6 nM of BRD4(C) Kd = 90.1 nM of BRD3(C) Kd = 128 nM, IC50 = 17.7 nM of BRD2(N) |
| Research Area |
MM AML MLL-rearranged leukemia |
| Target | BRD4 |
| References | [1]Delmore JE, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17. [2]Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. |
| Purity | >98% |
| Solubility | DMSO |
| Form | Powder (Liquid in DMSO) |
| Transportation and Storage | Ship at 4°C. Store at -20°C or -80°C. |
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