6P13119
dBET1
Order Information
| Size | Catalog Price |
| 10 mM* 1 mL in DMSO | ￥ 2246.00 |
| 1 mg | ￥ 680.00 |
| 5 mg | ￥ 1450.00 |
| 10 mg | ￥ 2600.00 |
| 50 mg | ￥ 9100.00 |
| 100 mg | ￥ 16000.00 |
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Western blot analysis of different concentration treatment of dBET1
Antigen: Extracts from MV4;11 cells after treatment with different concentration of dBET1 for 16 h
Concentrations and antibodies used are shown in the figure
| Product Name | dBET1 |
| Alternative Names | JQ1 based BET PROTAC1 |
| Formula | C38H37ClN8O7S |
| Molecular Weight | 785.27 |
| IUPAC | (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| CAS No. | 1799711-21-9 |
| Working Concentration | 100 - 1000 nM |
| Parental Inhibitor | (+)-JQ1 |
| E3 Ligase Ligand | Thalidomide |
| Bioactivity Data[1] |
EC50 = 430 nM of BRD4 IC50 = 0.14 μM in MV4;11 cells |
| Research Area |
MM AML MLL-rearranged leukemia |
| Target | BRD4 |
| E3 Ligase | CRBN |
| References | [1]Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81. |
| Purity | 98.4% |
| Solubility | DMSO |
| Form | Powder (Liquid in DMSO) |
| Transportation and Storage | Ship at 4°C. Store at -20°C or -80°C. |
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