Customized Antibody Service

Antibody-Preparation

The application of monoclonal antibodies has penetrated to the various fields of life science and biomedicine. It can be applied to almost all of the antigenic material, and monoclonal antibodies can be generated against a single antigen epitope. With the cloning of cDNA with unknown function, the research needs in research of the complicated function of genes and proteins increases. Effective preparation for a single protein epitope of monoclonal antibodies has become an indispensable tool in the study of gene and protein function.

Shanghai Genomics Technology has a strong advantage in hardware and software with experienced technical experts. We are customer-oriented and provide one-stop service in antibody preparation and purification. We can assist you to get the desired monoclonal antibody easily. Meanwhile, we can also provide a rabbit polyclonal antibody preparation service. We are especially experienced in antibodies recognizing special modified amino acids, thus can meet the various needs of different customers.

Customized antibodies provided by SGT have been cited in these Literatures:

Chen PH, et al. Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell. 2019 Dec 5;76(5):838-851.e5.

Yu T, et al. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun. 2019 Sep 25;10(1):4353.

Chen D, et al. Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov. 2019 Jun;9(6):756-777.

Han T, et al. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Res. 2018 Jun;28(6):655-669.

Chen Y, et al. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. Nat Commun. 2018 Jun 25;9(1):2464.

Li FL, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 Feb 6;9(1):508.

Wu Y, et al. A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A. Cell Discov. 2016 May 24;2:16014.

Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.

Wang S, et al. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Sep 10;13(9):e1002243.

Zhao D, et al. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014 Dec;124(12):5453‐5465.

Lv L, et al. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell. 2013 Nov 7;52(3):340-52.

Lin R, et al. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-518.

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