6P15219
MS4078
Order Information
| Size | Catalog Price |
| 10 mM* 1 mL in DMSO | ￥ 9800.00 |
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| Product Name | MS4078 |
| Alternative Names | Ceritinib based ALK PROTAC2 |
| Formula | C45H52ClN9O8S |
| Molecular Weight | 914.47 |
| IUPAC | 2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide |
| CAS No. | 2229036-62-6 |
| Working Concentration | 1 - 100 nM |
| Parental Inhibitor | Ceritinib |
| E3 Ligase Ligand | Pomalidomide |
| Bioactivity Data[1] |
Kd = 19 ± 3 nM DC50 = 11 ± 2 nM, IC50 = 33 ± 1 nM in SU-DHL-1 cells DC50 = 59 ± 16 nM in NCI-H2228 cells |
| Research Area |
ALCL NSCLC |
| Target | ALK |
| E3 Ligase | CRBN |
| References | [1]Zhang C, et al. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). Eur J Med Chem. 2018 May 10;151:304-314. |
| Purity | N/A |
| Solubility | DMSO |
| Form | Liquid |
| Transportation and Storage | Ship at 4°C. Store at -20°C or -80°C. |
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