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6P15170

Ceritinib

 

 

Order Information

Size Catalog Price
10 mM* 1 mL in DMSO ￥ 675.00
1 mg ￥ 180.00
5 mg ￥ 550.00
10 mg ￥ 770.00
50 mg ￥ 2300.00
100 mg ￥ 3300.00

 

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Product Name Ceritinib
Alternative Names LDK 378; LDK378; LDK-378; Eritinib
Formula C28H36ClN5O3S
Molecular Weight 558.14
IUPAC 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine
CAS No. 1032900-25-6
Working Concentration 0.2 - 50 nM
Bioactivity Data[2]

Kd = 1.3 ± 0.2 nM

IC50 = 200 pM in ALK enzymatic assay

IC50 = 25 nM in various cell-based assays
Research Area

ALCL

NSCLC
Target ALK
References [1]Shaw AT, et al. Ceritinib versus chemotherapy in patients with ALK-rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017 Jul;18(7):874-886.
[2]Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90.
Purity >98%
Solubility DMSO
Form Powder (Liquid in DMSO)
Transportation and Storage Ship at 4°C. Store at -20°C or -80°C.

 

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