6P15119
MS4077
Order Information
| Size | Catalog Price |
| 10 mM* 1 mL in DMSO | ￥ 9800.00 |
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| Product Name | MS4077 |
| Alternative Names | Ceritinib based ALK PROTAC1 |
| Formula | C55H72ClN9O13S |
| Molecular Weight | 1134.73 |
| IUPAC | 2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)acetamide |
| CAS No. | 2230077-10-6 |
| Working Concentration | 1 - 100 nM |
| Parental Inhibitor | Ceritinib |
| E3 Ligase Ligand | Pomalidomide |
| Bioactivity Data[1] |
Kd = 37 ± 4 nM DC50 = 3 ± 1 nM, IC50 = 46 ± 4 nM in SU-DHL-1 cells DC50 = 34 ± 9 nM in NCI-H2228 cells |
| Research Area |
ALCL NSCLC |
| Target | ALK |
| E3 Ligase | CRBN |
| References | [1]Zhang C, et al. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). Eur J Med Chem. 2018 May 10;151:304-314. |
| Purity | N/A |
| Solubility | DMSO |
| Form | Liquid |
| Transportation and Storage | Ship at 4°C. Store at -20°C or -80°C. |
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