SNIPER

SNIPERs (Specific and Non-genetic Inhibitor of apoptosis protein [IAP]-dependent Protein ERaser), recognised as a kind of PROTACs, induce the degradation of both POIs and cIAP1, which may limit the full potential and duration of knockdown activity. However, cIAP1 is an antiapoptotic protein frequently overexpressed in human tumor cells, which is believed to be involved in resistance to tumor therapy. Therefore, degradation of cIAP1 simultaneously with POIs by SNIPERs could be beneficial to effectively kill cancer cells.

References:

Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med. 2001 Jul;7(7):314-9.
Kaufmann SH, Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 2001 Dec;11(12):526-34.
Brumatti G, et al. 'Did He Who Made the Lamb Make Thee?' New Developments in Treating the 'Fearful Symmetry' of Acute Myeloid Leukemia. Trends Mol Med. 2017 Mar;23(3):264-281.
Syeda K, et al. Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine. Biochem Pharmacol. 2013 Nov 1;86(9):1338-46.
Hlongwane P, et al. Human Granzyme B Based Targeted Cytolytic Fusion Proteins. Biomedicines. 2018 Jun 20;6(2). pii: E72.